CHANNELS, CHIPS and NANOPORES : Biosensing with Channels

vendredi 21 mai 2010

In biological systems, ions and macromolecules are transported across lipid membranes by highly selective nanoscaled protein channels. The study of these transport processes and their imitation in artificial structures, fabricated by chemical synthesis and micro-fabrication, offer many opportunities for applications in ultrasensitive detection of molecules : rapid sequencing of DNA or RNA, studies of conformation (secondary structure of RNA, protein folding), or molecular interaction between proteins or between proteins and nucleic acids.

Online information

The area attracts many researchers from different disciplines : biologists, physicists, chemists and engineers. Classes are devoted to be accessible to multidisciplinary students. They will be given by internationally recognized speakers. Participating students and postdocs will have the opportunity to present and discuss their own research in poster sessions and student seminars.

Topics :
- natural channels : ion channels, mechano-sensitive channels, porins, toxins, nuclear pores, translocons,
- natural processes of transport of ions and macromolecules : biopolymer synthesis, transport of nucleic acids through nuclear pores, infection of cells by viruses, translocation and secretion of proteins,
- biophysics of lipid membranes, fusion, fission, poration, exo- and endocytosis,
- chemical synthesis of artificial channels,
- microfabrication, functionalization and use of artificial nanopores and nanotubes,
- electrical and optical detection of the transport of molecules at the scale of one single channel,
- proteins translocation and folding,
- forces measurement and conformations detection by translocation,
- physics of confined polymers,
- lipid bilayers and channels based biosensors,
- electronic detection of bio-macromolecules.

Documents joints

Biosensing with channels
Biosensing with channels
Summer school poster

Les nanos c'est: